Long-term proton pump inhibitor administration, H pylori and gastric cancer: lessons from the gerbil.
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منابع مشابه
Proton pump inhibitors and helicobacter pylori-associated pathogenesis.
The fact that long-term use of proton pump inhibitors (PPIs) aggravates corpus atrophic gastritis in patients with Helicobacter pylori infection has been proven clinically and experimentally. Corpus atrophic gastritis is a known risk factor for gastric cancer. Therefore, gastric neoplasia might be associated with the long-term use of PPIs. One of the causes of worsening corpus atrophic gastriti...
متن کاملHelicobacter pylori infection and long term proton pump inhibitor therapy.
S hould Helicobacter pylori infection be eradicated in patients requiring maintenance proton pump inhibitor therapy for gastro-oesophageal reflux disease? This question has stimulated heated debate and contention over the past few years. The issue first came to prominence in 1996 when Kuipers et al published their study purporting to demonstrate that omeprazole accelerated the development of co...
متن کاملProton pump inhibitors and Helicobacter pylori gastritis: friends or foes?
H. pylori gastritis and gastric acid closely interact. In H. pylori-positive patients, profound acid suppressive therapy induces a corpus-predominant pangastritis, which is associated with accelerated corpus gland loss and development of atrophic gastritis. Both corpus-predominant and atrophic gastritis have been associated with an increased risk of development of gastric cancer. H. pylori erad...
متن کاملAntagonist: Should we eradicate Helicobacter pylori before long term antireflux therapy?
Helicobacter pylori infection invariably induces chronic active gastritis which can give rise to serious consequences such as peptic ulcer and gastric malignancies. Generally accepted indications for treatment are H pylori associated peptic ulcer disease and early stages of low grade mucosa associated lymphoid tissue lymphoma of the stomach. In contrast, treatment of H pylori in patients with g...
متن کاملSystematic review: the effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology.
BACKGROUND Proton pump inhibitors (PPIs) have a well-established safety profile. However, concerns have been raised about a potential relationship between PPI-induced hypergastrinaemia and the development of enterochromaffin-like (ECL) cell hyperplasia, neuroendocrine tumours and gastric cancer during long-term therapy. AIM To review the effects of long-term PPI use on serum gastrin levels an...
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عنوان ژورنال:
- Gut
دوره 60 5 شماره
صفحات -
تاریخ انتشار 2011